生物
转录组
基因
基因表达
发育生物学
恒河猴
器官发生
基因表达调控
基因表达谱
进化生物学
遗传学
作者
Margarida Cardoso-Moreira,Jean Halbert,Delphine Valloton,Britta Velten,Chunyan Chen,Yi Shao,Angélica Liechti,Kelly Ascenção,Coralie Rummel,Svetlana Ovchinnikova,Pavel Mazin,Ioannis Xénarios,Keith Harshman,Matthew Mort,D.N. Cooper,Carmen Sandi,Michael J. Soares,Paula G. Ferreira,Sandra Afonso,Miguel Carneiro
出处
期刊:Nature
[Springer Nature]
日期:2019-06-26
卷期号:571 (7766): 505-509
被引量:729
标识
DOI:10.1038/s41586-019-1338-5
摘要
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs. The transcriptomes of seven major organs across developmental stages from several mammalian species are used for comparative analyses of gene expression and evolution across organ development.
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