CX3CR1型
串扰
CX3CL1型
Wnt信号通路
趋化因子
信号转导
炎症
细胞生物学
趋化性
MAPK/ERK通路
免疫学
癌症研究
生物
受体
趋化因子受体
生物化学
光学
物理
作者
Quan Zhuang,Jiarui Ou,Sheng Zhang,Yingzi Ming
出处
期刊:Current Protein & Peptide Science
[Bentham Science]
日期:2019-03-07
卷期号:20 (8): 844-854
被引量:37
标识
DOI:10.2174/1389203720666190305165722
摘要
During inflammation, chemokines play a central role by mediating the activation of inflammatory cascade responses in tissue injury. Among more than 200 chemokines, CX3CL1 is a special chemotactic factor existing in both membrane-bound and soluble forms. Its only receptor, CX3CR1, is a member of the G protein-coupled receptor superfamily. The CX3CL1/CX3CR1 axis can affect many inflammatory processes by communicating with different inflammatory signaling pathways, such as JAK-STAT, Toll-like receptor, MAPK, AKT, NF-κB, Wnt/β-catenin, as well as others. These inflammatory networks are involved in much pathology. Determining the crosstalk between the CX3CL1/CX3CR1 axis and these inflammatory signaling pathways could contribute to solving problems in tissue injury, and the CX3CL1/CX3CR1 axis may be a better therapeutic target than inflammatory signaling pathways for preventing tissue injury due to the complexity of inflammatory signaling networks.
科研通智能强力驱动
Strongly Powered by AbleSci AI