医学
肌萎缩
尿路上皮癌
危险系数
内科学
置信区间
荟萃分析
科克伦图书馆
泌尿科
肿瘤科
前瞻性队列研究
癌
泌尿系统
胃肠病学
癌症
膀胱癌
作者
Xu Hu,Wei-Chao Dou,Yanxiang Shao,Jianbang Liu,San-Chao Xiong,Weixiao Yang,Xiang Li
出处
期刊:Ejso
[Elsevier]
日期:2019-05-01
卷期号:45 (5): 747-754
被引量:26
标识
DOI:10.1016/j.ejso.2019.03.003
摘要
Sarcopenia is associated with unfavorable prognosis in patients undergoing surgical treatments of the respiratory tract, gastrointestinal tract and urinary tracts. We summarized all available evidence to investigate the prognostic value of sarcopenia in patients with surgically treated urothelial carcinoma (UC).We conducted a comprehensive study search up to January 2019, searching the online database Embase, PubMed and Cochrane Library. The hazard ratio (HR) and 95% confidence interval (CI) were extracted from the studies.A total of 12 research consisting of 2075 patients were enrolled in the quantitative synthesis. We observed that UC patients with sarcopenia had a worse OS (HR = 1.87; 95%CI 1.43-2.45; P < 0.001) and CSS (HR = 1.98; 95%CI 1.43-2.75; P < 0.001). Stratified by tumor, sarcopenia is also an unfavorable factor for OS and CSS in patients with upper tract urothelial carcinoma (UTUC) or urothelial carcinoma of bladder (UCB).Sarcopenia is an unfavorable factor for OS and CSS in patients with surgically treated UC. Besides, stratified by tumor, the results of patients with UTUC or UCB are consistent with previous results. More prospective studies are required to validate our findings.
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