Meta-analysis of the relationship between depression and diabetic retinopathy

Objective: To study the correlation between depression and the risk of Diabetic Retinopathy (DR). Methods: A total of 268 articles were obtained from PubMed, Web of Science, Science Direct and Ovid between January 2000 and September 2017, combined with retrospective retrieval of literature. Stata12.0 was utilized for statistical data and the OR (95% CI) values were obtained by means of metaanalysis. Results: A total of 4912 cases and 11641 controls were incorporated in the study from 19 literatures. The results of the meta-analysis demonstrated that the combined OR (95% CI) value was 1.43 (1.21-1.69), while the risk of DR in patients with diabetes mellitus was augmented by 0.43 times than that in the normal diabetic patients. After grouping of diabetic patients, the combined OR (95% CI) value was 2.18 (0.91-5.24), 1.5 (1.18-1.92) and 1.15 (0.87-1.52), respectively. On the other hand, after grouping of different subjects, the OR (95% CI) value was 1.28 (1.03-1.59) and 1.62 (1.28-2.06), respectively. Conclusion: Depression is among the substantial risk factors for the pathogenesis of DR. The targeted intervention will help in reducing the risk of DR.