Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database

指炎 巴斯菲 巴斯代人 医学 强直性脊柱炎 内科学 HLA-B27 血沉 银屑病性关节炎 脊柱炎 银屑病 优势比 末端炎 痹症科 置信区间 胃肠病学 关节炎 免疫学 人类白细胞抗原 抗原
作者
M. Arévalo,Jordi Gratacós,Mireia Moreno,J. Calvet,C. Orellana,D. Ruiz,Carmen Castro,Pilar Carreto,M. Larrosa,Eduardo Collantes‐Estévez,Pilar Font
出处
期刊:Arthritis Research & Therapy [BioMed Central]
卷期号:20 (1) 被引量:76
标识
DOI:10.1186/s13075-018-1724-7
摘要

To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients. An observational, cross-sectional and descriptive study of AS patients from the Spanish REGISPONSER database was performed. Demographic, clinical, disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)), and radiographic data (Bath Ankylosing Spondylitis Radiology Index (BASRI) score) were compared regarding HLA-B27 status. A univariate and multivariate analysis was performed to identify variables independently related to the presence of HLA-B27. Data from 1235 patients (74.8% male) were analyzed; 1029 were HLA-B27 positive (83%). HLA-B27-positive patients showed higher family aggregation and an earlier onset of disease compared with those who were HLA-B27 negative. HLA-B27-negative patients presented statistically higher BASDAI and BASFI scores and higher prevalence of arthritis, dactylitis, and extra-articular manifestations (psoriasis and inflammatory bowel disease (IBD)) but not anytime uveitis compared with those who were HLA-B27 positive. In the multivariate analysis, family history (odds ratio (OR) 2.10, 95% confidence interval (CI) 1.27–3.49), younger age at diagnosis (OR 0.97, 95% CI 0.96–0.98), presence of peripheral arthritis (OR 0.53, 95% CI 0.32–0.89), dactylitis (OR 0.16, 95% CI 0.05–0.56), psoriasis (OR 0.45, 95% CI 0.26–0.78), and IBD (OR 0.22, 95% CI 0.12–0.40) were the main variables independently related to the presence or not of HLA-B27. In Caucasian AS patients, the presence of HLA-B27 is related to an earlier disease onset and higher family aggregation. Absence of HLA-B27 is related to a higher frequency of peripheral arthritis, dactylitis, and extra-articular manifestations. Being HLAB27 positive is not related to a higher burden of disease or anytime uveitis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
善学以致用应助Cloud采纳,获得10
刚刚
1秒前
1秒前
3秒前
kesong发布了新的文献求助10
4秒前
Rain发布了新的文献求助10
7秒前
蒋丞完成签到,获得积分10
7秒前
8秒前
9秒前
9秒前
生动惜灵完成签到,获得积分10
10秒前
11秒前
Pool完成签到 ,获得积分10
12秒前
隐形曼青应助郭小宝采纳,获得10
12秒前
自由从筠完成签到 ,获得积分10
12秒前
Jasper应助俏皮的白柏采纳,获得10
14秒前
量子星尘发布了新的文献求助10
14秒前
14秒前
幽默果汁完成签到 ,获得积分10
14秒前
14秒前
生动惜灵发布了新的文献求助10
15秒前
背后海亦应助微笑的绿竹采纳,获得20
17秒前
科研通AI5应助科研通管家采纳,获得10
17秒前
领导范儿应助科研通管家采纳,获得10
17秒前
17秒前
18秒前
18秒前
李健应助科研通管家采纳,获得10
18秒前
18秒前
18秒前
wanci应助科研通管家采纳,获得10
18秒前
方格发布了新的文献求助10
19秒前
寄语明月发布了新的文献求助30
23秒前
17377758395完成签到,获得积分10
23秒前
牛马发布了新的文献求助10
25秒前
25秒前
26秒前
26秒前
酷波er应助论文侠采纳,获得10
26秒前
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988997
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253520
捐赠科研通 3269928
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882063
科研通“疑难数据库(出版商)”最低求助积分说明 809068