Sarcopenia and Low Serum Albumin Level Synergistically Increase the Risk of Incident Disability in Older Adults

医学 肌萎缩 老年学 血清白蛋白 内科学 白蛋白
作者
Kazuki Uemura,Takehiko Doi,Sungchul Lee,Hiroyuki Shimada
出处
期刊:Journal of the American Medical Directors Association [Elsevier BV]
卷期号:20 (1): 90-93 被引量:68
标识
DOI:10.1016/j.jamda.2018.06.011
摘要

Abstract

Objectives

This study aimed to investigate the additive effects of sarcopenia and low serum albumin level on the risk of incident disability in older adults.

Design

Prospective cohort study.

Setting

A Japanese community.

Participants

Community-dwelling older adults aged ≥65 years, without disability at baseline (N = 4452).

Measures

Sarcopenia was defined as the presence of both poor muscle function (low physical performance or muscle strength) and low muscle mass. Low serum albumin level was defined as ≤4.0 g/dL. Other potential confounding factors (demographics, medical history, depressive symptoms, and cognitive function) were also assessed. Incident disability was monitored based on Long-Term Care Insurance certification during follow-up.

Results

The median follow-up duration was 30 (interquartile range, 28-32) months. Participants were classified into mutually exclusive groups based on sarcopenia status and serum albumin levels: nonsarcopenia/normal serum albumin (n = 3719), low serum albumin alone (n = 552), sarcopenia alone (n = 132), and sarcopenia/low serum albumin (n = 49). A Cox hazards regression showed that the low serum albumin alone [hazard ratios (HR) = 1.71, 95% confidence interval (CI) = 1.26-2.33], sarcopenia alone (HR = 2.74, 95% CI = 1.58-4.77), and sarcopenia/low serum albumin groups (HR = 3.73, 95% CI = 1.87-7.44) had higher risk of disability than the nonsarcopenia/normal serum albumin group after adjusting for the covariates.

Conclusions/Implications

Sarcopenia and low serum albumin level synergistically increase the risk of incident disability in older adults. Sarcopenia in older adults at risk of malnutrition should be detected early, and appropriate interventions should be implemented.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
含糊的代丝完成签到 ,获得积分10
3秒前
朴素的紫安完成签到 ,获得积分10
4秒前
yyj完成签到,获得积分10
5秒前
6秒前
6秒前
量子星尘发布了新的文献求助10
6秒前
君临完成签到,获得积分10
6秒前
林早上完成签到,获得积分20
6秒前
xiu完成签到 ,获得积分10
7秒前
栗爷完成签到,获得积分0
7秒前
深年完成签到,获得积分10
8秒前
求知若渴完成签到,获得积分0
8秒前
所所应助科研通管家采纳,获得10
8秒前
情怀应助科研通管家采纳,获得10
8秒前
华仔应助科研通管家采纳,获得30
8秒前
李爱国应助科研通管家采纳,获得10
9秒前
Orange应助科研通管家采纳,获得10
9秒前
我是老大应助科研通管家采纳,获得10
9秒前
华仔应助科研通管家采纳,获得10
9秒前
SciGPT应助科研通管家采纳,获得10
9秒前
9秒前
一团小煤球完成签到,获得积分10
9秒前
9秒前
NexusExplorer应助科研通管家采纳,获得10
9秒前
9秒前
9秒前
卡乐瑞咩吹可完成签到,获得积分10
9秒前
田様应助科研通管家采纳,获得10
9秒前
苦咖啡行僧完成签到 ,获得积分10
9秒前
鹤鸣完成签到,获得积分10
10秒前
守望阳光1完成签到,获得积分10
10秒前
正直天空发布了新的文献求助10
10秒前
12秒前
YU发布了新的文献求助10
12秒前
大方元风完成签到 ,获得积分10
12秒前
隐形曼青应助自觉寒梦采纳,获得10
13秒前
ntxlks完成签到,获得积分10
13秒前
祝雲完成签到,获得积分10
13秒前
Spice完成签到 ,获得积分10
14秒前
John完成签到,获得积分20
14秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029