Highly Enantioselective Organocatalytic Conjugate Addition of Nitromethane to α,β‐Unsaturated Aldehydes: Three‐Step Synthesis of Optically Active Baclofen

Abstract An efficient, organocatalytic, highly enantioselective, conjugate addition reaction of nitromethane with α,β‐unsaturated aldehydes has been developed. The process serves as the key step for a practical 3‐step synthesis of chiral baclofen, an antispastic drug.