医学
内科学
心脏病学
优势比
逻辑回归
冠状动脉疾病
甘油三酯
入射(几何)
钙化
风险因素
胆固醇
光学
物理
作者
Kahui Park,Chul Woo Ahn,Sang Bae Lee,Shinae Kang,Ji Sun Nam,Byoung Kwon Lee,Jung Hye Kim,Jong Suk Park
出处
期刊:Diabetes Care
[American Diabetes Association]
日期:2019-06-10
卷期号:42 (8): 1569-1573
被引量:214
摘要
OBJECTIVE To investigate the triglyceride-glucose (TyG) index association with coronary artery calcification (CAC) progression in adult Koreans. RESEARCH DESIGN AND METHODS Various cardiovascular risk factors and anthropometric profiles were assessed in 1,175 subjects who previously had a CAC evaluation at least twice by multidetector computed tomography in a health care center. The TyG index was determined using ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). The CAC progression was defined as either incident CAC in a CAC-free population at baseline or an increase of ≥2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACSs) of subjects with detectable CAC at baseline. RESULTS CAC progression was seen in 312 subjects (27%) during 4.2 years follow-up. On the basis of the TyG index, subjects were stratified into three groups. Follow-up CACS and incidence of CAC progression were markedly elevated with rising TyG index tertile. Logistic regression analysis adjusted for various risk factors revealed an odds ratio for CAC progression of 1.82 (95% CI 1.20–2.77; P ≤ 0.01) when the highest and lowest TyG index tertiles were compared. CONCLUSIONS The TyG index is an independent predictor of CAC progression.
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