Chitosan-Based Carbon Quantum Dots for Biomedical Applications: Synthesis and Characterization

纳米材料 壳聚糖 量子点 量子产额 纳米技术 碳量子点 细胞毒性 化学 药物输送 生物相容性材料 碳纤维 材料科学 荧光 有机化学 生物化学 体外 生物医学工程 医学 物理 量子力学 复合数 复合材料
作者
Łukasz Janus,Marek Piątkowski,Julia Radwan-Pragłowska,Dariusz Bogdał,Dalibor Matýsek
出处
期刊:Nanomaterials [MDPI AG]
卷期号:9 (2): 274-274 被引量:84
标识
DOI:10.3390/nano9020274
摘要

Rapid development in medicine and pharmacy has created a need for novel biomaterials with advanced properties such as photoluminescence, biocompability and long-term stability. The following research deals with the preparation of novel types of N-doped chitosan-based carbon quantum dots. Nanomaterials were obtained with simultaneous nitrogen-doping using biocompatible amino acids according to Green Chemistry principles. For the carbon quantum dots synthesis chitosan was used as a raw material known for its biocompability. The nanomaterials obtained in the form of lyophilic colloids were characterized by spectroscopic and spectrofluorimetric methods. Their quantum yields were determined. Additionally the cytotoxicity of the prepared bionanomaterials was evaluated by XTT (2,3-Bis-(2-methoxy-4-nitro5-sulfophenyl)-2H-tetrazolium-5-carboxanilide salt) method. Our results confirmed the formation of biocompatible quantum dots with carbon cores exhibiting luminescence in visible range. Performed studies showed that modification with lysine (11.5%) and glutamic acid (7.4%) had a high impact on quantum yield, whereas functionalization with amino acids rich in S and N atoms did not significantly increase in fluorescence properties. XTT assays as well as morphological studies on human dermal fibroblasts confirmed the lack of cytotoxicity of the prepared bionanomaterials. The study shows chitosan-based quantum dots to be promising for biomedical applications such as cell labelling, diagnostics or controlled drug delivery and release systems.
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