Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization.

The adenovirus E1a oncoprotein targets a number of negative regulators of cellular proliferation, including the retinoblastoma gene product RB, p107, p130, p300, and the CREB-binding protein (CBP). p300 and CBP are highly homologous proteins that are thought to function as transcriptional coactivators, with roles in the regulation of the cell cycle and in cell differentiation. Like the RB protein, these proteins also may function as tumor suppressors. We have mapped the chromosomal location of the human CBP gene 3 as a first step in defining its possible involvement in human neoplasia. 11 refs.