核医学
肺癌
单光子发射计算机断层摄影术
医学
图像配准
通风(建筑)
放射治疗
放射治疗计划
计算机断层摄影术
放射科
物理
计算机科学
病理
人工智能
热力学
图像(数学)
作者
Fiona Hegi‐Johnson,Paul Keall,Jeff Barber,Chuong Bui,John Kipritidis
摘要
Purpose Computed tomography ventilation imaging (CTVI) is a highly accessible functional lung imaging modality that can unlock the potential for functional avoidance in lung cancer radiation therapy. Previous attempts to validate CTVI against clinical ventilation single‐photon emission computed tomography (V‐SPECT) have been hindered by radioaerosol clumping artifacts. This work builds on those studies by performing the first comparison of CTVI with 99m Tc‐carbon (‘Technegas’), a clinical V‐SPECT modality featuring smaller radioaerosol particles with less clumping. Methods Eleven lung cancer radiotherapy patients with early stage (T1/T2N0) disease received treatment planning four‐dimensional CT (4DCT) scans paired with Technegas V/Q‐SPECT/CT. For each patient, we applied three different CTVI methods. Two of these used deformable image registration (DIR) to quantify breathing‐induced lung density changes (CTVI DIR‐HU ), or breathing‐induced lung volume changes (CTVI DIR‐Jac ) between the 4DCT exhale/inhale phases. A third method calculated the regional product of air‐tissue densities (CTVI HU ) and did not involve DIR. Corresponding CTVI and V‐SPECT scans were compared using the Dice similarity coefficient (DSC) for functional defect and nondefect regions, as well as the Spearman's correlation r computed over the whole lung. The DIR target registration error (TRE) was quantified using both manual and computer‐selected anatomic landmarks. Results Interestingly, the overall best performing method (CTVI HU ) did not involve DIR. For nondefect regions, the CTVI HU , CTVI DIR‐HU , and CTVI DIR‐Jac methods achieved mean DSC values of 0.69, 0.68, and 0.54, respectively. For defect regions, the respective DSC values were moderate: 0.39, 0.33, and 0.44. The Spearman r ‐values were generally weak: 0.26 for CTVI HU , 0.18 for CTVI DIR‐HU , and −0.02 for CTVI DIR‐Jac . The spatial accuracy of CTVI was not significantly correlated with TRE, however the DIR accuracy itself was poor with TRE > 3.6 mm on average, potentially indicative of poor quality 4DCT. Q‐SPECT scans achieved good correlations with V‐SPECT (mean r > 0.6), suggesting that the image quality of Technegas V‐SPECT was not a limiting factor in this study. Conclusions We performed a validation of CTVI using clinically available 4DCT and Technegas V/Q‐SPECT for 11 lung cancer patients. The results reinforce earlier findings that the spatial accuracy of CTVI exhibits significant interpatient and intermethod variability. We propose that the most likely factor affecting CTVI accuracy was poor image quality of clinical 4DCT.
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