页面ID
医学
头皮
异型性
皮肤病科
黑色素瘤
痣
黑色素细胞痣
病理
癌症研究
作者
Christine Ahn,Analía Guerra,Omar P. Sangüeza
出处
期刊:American Journal of Dermatopathology
[Ovid Technologies (Wolters Kluwer)]
日期:2016-11-22
卷期号:38 (12): 867-881
被引量:36
标识
DOI:10.1097/dad.0000000000000568
摘要
Abstract: Melanocytic nevi located on specific regions of the body can demonstrate unusual histopathological features such as asymmetry, irregular nesting patterns, pagetoid spread, cytologic atypia, and rarely, mitotic activity. However, despite these features that may raise concern for malignant melanoma, these lesions follow a benign clinical course and do not require intervention. Also known as nevi of special sites or nevi with site-related atypia, these melanocytic nevi were initially described on acral sites and genitalia. Now, additional anatomical sites with known site-related atypia include the ear, conjunctivae, scalp, breast, flexural skin, legs, and back and shoulder. This continuing medical education article presents a review of the histopathological characteristics of special site nevi based on anatomic location. It is imperative for dermatologists, pathologists, and dermatopathologists to distinguish benign melanocytic nevi with site-related atypia from malignant melanoma to avoid unnecessary surgical intervention or treatment.
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