微管
驱动蛋白
生物物理学
细胞生物学
运动蛋白
运动性
生物
人口
分子马达
化学
生物化学
社会学
人口学
作者
Geng-Yuan Chen,You-Jung Kang,A. Sophia Gayek,Wiphu Youyen,Erkan Tüzel,Ryoma Ohi,William O. Hancock
标识
DOI:10.1016/j.bpj.2016.11.2284
摘要
The goal of this work was to investigate the mechanisms underlying different Eg5 (kinesin-5) inhibitors and to assess their effects on Eg5-mediated stabilization of dynamic microtubules. Antimitotic Eg5 inhibitors were grouped into those that bind Loop-5 and produce an ADP-like state (monastrol, STLC, ispinesib and filanesib) and those that produce a rigor-like state (BRD9876). To understand their contrasting effects on Eg5 mechanics, inhibitors were analyzed in mixed-motor gliding assays consisting of different ratios of kinesin-1 and Eg5 motors, in which Eg5 "braking" dominates motility.
科研通智能强力驱动
Strongly Powered by AbleSci AI