Associations of physical activity and fitness with hepatic steatosis, liver enzymes, and insulin resistance in children with overweight/obesity

胰岛素抵抗 内科学 医学 超重 内分泌学 脂肪变性 心肺适能 肥胖 胰岛素 丙氨酸转氨酶 甘油三酯 γ-谷氨酰转移酶 胆固醇 生物 生物化学
作者
María Medrano,Lide Arenaza,Jairo H. Migueles,Beatriz Rodríguez‐Vigil,Jonatan R. Ruiz,Idoia Labayen
出处
期刊:Pediatric Diabetes [Wiley]
卷期号:21 (4): 565-574 被引量:22
标识
DOI:10.1111/pedi.13011
摘要

Background Non-alcoholic fatty liver disease is the most common liver disease in childhood and is related to insulin resistance and cardiometabolic risk factors. Evidence supporting the association of fitness and physical activity with hepatic fat, liver enzymes, or triglyceride-to-high-density lipoprotein ratio is scarce in children. Objective To analyze the associations of physical fitness and physical activity (PA) with percentage hepatic fat, liver enzymes, insulin resistance, and cardiometabolic risk in children with overweight/obesity. Subjects A total of 115 children (10.6 ± 1.1 years; 54% girls) with overweight/obesity of the EFIGRO study (ClinicalTrials.gov: NCT02258126) were included in the analyses. Methods Cardiorespiratory fitness (CRF), musculoskeletal fitness and speed-agility were measured by the Alpha-fitness tests, and PA by wGT3X-BT accelerometers. Percentage hepatic fat was assessed by magnetic resonance imaging. Alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), insulin, glucose, triglycerides (TG), and high-density lipoprotein (HDL) levels were obtained from fasting blood samples. The homeostasis model assessment insulin resistance (HOMA-IR) and AST/ALT and TG/HDL ratios were calculated. Results Higher CRF was associated with lower percentage hepatic fat (β = −0.266, P = .01) and GGT (β = −0.315, P < .01), and higher AST/ALT ratio (β = 0.306, P < .01). CRF-fit children have lower GGT levels (15 ± 1 vs 17 ± 1 U/L, CRF-fit vs CRF-unfit children, P = .02), HOMA-IR (2.2 ± 0.1 vs 2.9 ± 0.1, P < .01) and TG/HDL ratio (1.4 ± 0.1 vs 1.9 ± 0.1, P = .01) and higher AST/ALT ratio (1.3 ± 0.0 vs 1.2 ± 0.0, P = .03), than CRF-unfit children. Conclusions These findings emphasize the importance of considering the improvement of CRF as a target of programs for preventing hepatic steatosis, type 2 diabetes and cardiovascular diseases in children with overweight.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
圈圈叉叉发布了新的文献求助10
2秒前
redking发布了新的文献求助10
2秒前
缥缈剑愁发布了新的文献求助10
3秒前
CodeCraft应助圆蓬蓬采纳,获得10
3秒前
zhaoyuli完成签到,获得积分10
3秒前
啊啊发布了新的文献求助10
3秒前
3秒前
ZH发布了新的文献求助10
5秒前
研友_VZG7GZ应助Endeavor采纳,获得10
5秒前
warden完成签到 ,获得积分10
5秒前
科研通AI2S应助sisyphus_yy采纳,获得10
6秒前
施天问发布了新的文献求助10
6秒前
8秒前
Singularity应助内向寒云采纳,获得10
8秒前
dd完成签到 ,获得积分10
8秒前
9秒前
Miracle发布了新的文献求助10
10秒前
开花完成签到,获得积分10
10秒前
量子星尘发布了新的文献求助10
11秒前
12秒前
redking完成签到,获得积分10
12秒前
lingquanmeng完成签到,获得积分10
13秒前
13秒前
羽生发布了新的文献求助10
13秒前
隐形曼青应助miumiu采纳,获得10
14秒前
beckham发布了新的文献求助10
15秒前
施天问完成签到,获得积分10
16秒前
uu发布了新的文献求助10
16秒前
17秒前
17秒前
17秒前
小蘑菇应助Miracle采纳,获得10
17秒前
轩轩轩轩完成签到 ,获得积分10
18秒前
18秒前
19秒前
litao完成签到,获得积分10
20秒前
乐乐应助九千七采纳,获得10
22秒前
梁三柏应助makabaka采纳,获得10
22秒前
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975755
求助须知:如何正确求助?哪些是违规求助? 3520108
关于积分的说明 11200829
捐赠科研通 3256492
什么是DOI,文献DOI怎么找? 1798298
邀请新用户注册赠送积分活动 877509
科研通“疑难数据库(出版商)”最低求助积分说明 806403