Associations of physical activity and fitness with hepatic steatosis, liver enzymes, and insulin resistance in children with overweight/obesity

胰岛素抵抗 内科学 医学 超重 内分泌学 脂肪变性 心肺适能 肥胖 胰岛素 丙氨酸转氨酶 甘油三酯 γ-谷氨酰转移酶 胆固醇 生物 生物化学
作者
María Medrano,Lide Arenaza,Jairo H. Migueles,Beatriz Rodríguez‐Vigil,Jonatan R. Ruiz,Idoia Labayen
出处
期刊:Pediatric Diabetes [Wiley]
卷期号:21 (4): 565-574 被引量:22
标识
DOI:10.1111/pedi.13011
摘要

Background Non-alcoholic fatty liver disease is the most common liver disease in childhood and is related to insulin resistance and cardiometabolic risk factors. Evidence supporting the association of fitness and physical activity with hepatic fat, liver enzymes, or triglyceride-to-high-density lipoprotein ratio is scarce in children. Objective To analyze the associations of physical fitness and physical activity (PA) with percentage hepatic fat, liver enzymes, insulin resistance, and cardiometabolic risk in children with overweight/obesity. Subjects A total of 115 children (10.6 ± 1.1 years; 54% girls) with overweight/obesity of the EFIGRO study (ClinicalTrials.gov: NCT02258126) were included in the analyses. Methods Cardiorespiratory fitness (CRF), musculoskeletal fitness and speed-agility were measured by the Alpha-fitness tests, and PA by wGT3X-BT accelerometers. Percentage hepatic fat was assessed by magnetic resonance imaging. Alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), insulin, glucose, triglycerides (TG), and high-density lipoprotein (HDL) levels were obtained from fasting blood samples. The homeostasis model assessment insulin resistance (HOMA-IR) and AST/ALT and TG/HDL ratios were calculated. Results Higher CRF was associated with lower percentage hepatic fat (β = −0.266, P = .01) and GGT (β = −0.315, P < .01), and higher AST/ALT ratio (β = 0.306, P < .01). CRF-fit children have lower GGT levels (15 ± 1 vs 17 ± 1 U/L, CRF-fit vs CRF-unfit children, P = .02), HOMA-IR (2.2 ± 0.1 vs 2.9 ± 0.1, P < .01) and TG/HDL ratio (1.4 ± 0.1 vs 1.9 ± 0.1, P = .01) and higher AST/ALT ratio (1.3 ± 0.0 vs 1.2 ± 0.0, P = .03), than CRF-unfit children. Conclusions These findings emphasize the importance of considering the improvement of CRF as a target of programs for preventing hepatic steatosis, type 2 diabetes and cardiovascular diseases in children with overweight.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
yabocai完成签到,获得积分10
刚刚
秀丽糖豆发布了新的文献求助10
刚刚
1秒前
时米米米完成签到,获得积分10
2秒前
无私语儿完成签到,获得积分10
2秒前
关键词完成签到,获得积分10
3秒前
6789发布了新的文献求助10
3秒前
st89225完成签到,获得积分10
4秒前
Fan完成签到,获得积分10
4秒前
yabocai发布了新的文献求助10
4秒前
5秒前
黄杰完成签到 ,获得积分10
5秒前
未名白发布了新的文献求助10
6秒前
qqqyy完成签到,获得积分10
8秒前
8秒前
lzh完成签到,获得积分20
8秒前
文风杰采完成签到,获得积分10
8秒前
时冬冬完成签到,获得积分0
8秒前
与我常在发布了新的文献求助20
8秒前
爆米花应助灯塔水母采纳,获得10
8秒前
常大有完成签到,获得积分10
8秒前
安静一曲完成签到 ,获得积分10
9秒前
HJJHJH完成签到,获得积分10
9秒前
满唐完成签到 ,获得积分10
10秒前
Xzx1995完成签到 ,获得积分10
10秒前
寒冷书竹完成签到,获得积分20
10秒前
曾曾完成签到,获得积分10
11秒前
11秒前
lvyan完成签到,获得积分10
11秒前
贫穷的塔姆完成签到,获得积分10
11秒前
危机的土豆完成签到,获得积分20
11秒前
粗犷的凌兰完成签到,获得积分10
12秒前
SciGPT应助zhizhiman采纳,获得10
12秒前
爱笑的曼易完成签到,获得积分10
12秒前
三木埃尔完成签到,获得积分10
12秒前
景绝义完成签到,获得积分10
13秒前
迷你的百川完成签到,获得积分10
13秒前
14秒前
坚定的迎波完成签到,获得积分10
14秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968637
求助须知:如何正确求助?哪些是违规求助? 3513552
关于积分的说明 11168493
捐赠科研通 3248935
什么是DOI,文献DOI怎么找? 1794554
邀请新用户注册赠送积分活动 875188
科研通“疑难数据库(出版商)”最低求助积分说明 804691