Development of a new comorbidity index for adults with cerebral palsy and comparative assessment with common comorbidity indices

共病 医学 内科学 逻辑回归 查尔森共病指数 比例危险模型 队列 置信区间 统计的 儿科 人口学 统计 数学 社会学
作者
Daniel G. Whitney,Neil Kamdar
出处
期刊:Developmental Medicine & Child Neurology [Wiley]
卷期号:63 (3): 313-319 被引量:26
标识
DOI:10.1111/dmcn.14759
摘要

Aim To develop a new comorbidity index for adults with cerebral palsy (CP), the Whitney Comorbidity Index (WCI), which includes relevant comorbidities for this population and better predicts mortality than the Charlson Comorbidity Index (CCI) and Elixhauser Comorbidity Index (ECI). Method Data from the Optum Clinformatics Data Mart was used for this retrospective cohort study. Diagnosis codes were used to identify adults aged 18 years or older with CP ( n =1511 females, n =1511 males; mean [SD; range] age=48y [19y 2mo; 18–89y]) and all comorbidities in the year 2014. The WCI was developed based on the comorbidities of the CCI and ECI and other relevant comorbidities associated with 2‐year mortality using Cox regression and competing risk analysis. The WCI was examined as unweighted (WCI unw ) and weighted (WCI w ). The model fit and discrimination (C‐statistic) of each index was assessed using Cox regression. Results Twenty‐seven comorbidities were included in the WCI; seven new comorbidities that were not part of the CCI or ECI were added. The WCI unw and WCI w showed a better model fit and discrimination for 1‐ and 2‐year mortality compared to the CCI and ECI. The WCI unw and WCI w were strong predictors for 1‐ and 2‐year mortality (C‐statistic [95% confidence interval] ranging from 0.81 [0.76–0.85] to 0.88 [0.82–0.94]). Interpretation The new WCI, designed to include clinically relevant comorbidities, provides a better model fit and discrimination of mortality for adults with CP. What this paper adds Common comorbidity indices exclude relevant comorbidities for adults with cerebral palsy (CP). A new comorbidity index for adults with CP was created by harmonizing clinical theory and data‐driven methods. The Whitney Comorbidity Index better predicted 1‐ and 2‐year mortality than other commonly used comorbidity indices.
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