生物正交化学
圣杯
化学
计算机科学
化学生物学
纳米技术
组合化学
生化工程
生物化学
点击化学
工程类
材料科学
万维网
作者
Karine Porte,Maxime Ribéraud,Rémi Châtre,Davide Audisio,Sébastien Papot,Frédéric Taran
出处
期刊:ChemBioChem
[Wiley]
日期:2020-11-02
卷期号:22 (1): 100-113
被引量:24
标识
DOI:10.1002/cbic.202000525
摘要
Abstract The advent of bioorthogonal chemistry has led to the development of powerful chemical tools that enable increasingly ambitious applications. In particular, these tools have made it possible to achieve what is considered to be the holy grail of many researchers involved in chemical biology: to perform unnatural chemical reactions within living organisms. In this minireview, we present an update of bioorthogonal reactions that have been carried out in animals for various applications. We outline the advances made in the understanding of fundamental biological processes, and the development of innovative imaging and therapeutic strategies using bioorthogonal chemistry.
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