柯蒂斯重排
化学
羧酸
小学(天文学)
亲核细胞
有机化学
氮气
组合化学
催化作用
天文
物理
作者
Arun Kumar,Naveen Kumar,Ritika Sharma,Gaurav Bhargava,Dinesh Mahajan
标识
DOI:10.1021/acs.joc.9b01697
摘要
Herein we report, a single-pot multistep conversion of inactivated carboxylic acids to various N-containing compounds using a common synthetic methodology. The developed methodology rendered the use of carboxylic acids as a direct surrogate of primary amines, for the synthesis of primary ureas, secondary/tertiary ureas, O/S-carbamates, benzoyl ureas, amides, and N-formyls, exploiting the Curtius reaction. This approach has a potential to provide a diversified library of N-containing compounds, starting from a single carboxylic acid, based on the selection of the nucleophile.
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