小RNA
系统性红斑狼疮
基因表达谱
表观遗传学
微阵列分析技术
微阵列
计算生物学
医学
生物信息学
基因
发病机制
基因表达调控
基因表达
疾病
生物
免疫学
遗传学
病理
作者
Forouzan Omidi,Sayed Abdolhakim Hosseini,Abbas Ahmadi,Kambiz Hassanzadeh,Shima Rajaei,Henry Manuel Cesaire,Vahedeh Hosseini
出处
期刊:Lupus
[SAGE]
日期:2020-07-28
卷期号:29 (11): 1321-1335
被引量:10
标识
DOI:10.1177/0961203320944473
摘要
Lupus is one of the most prevalent systemic autoimmune diseases. It is a multifactorial disease in which genetic, epigenetic and environmental factors play significant roles. The pathogenesis of lupus is not yet well understood. However, deregulation of microRNAs (miRNAs) – one of the post-transcriptional regulators of genes – can contribute to the development of autoimmune diseases. Over the last two decades, advances in the profiling of miRNA using microarray have received much attention, and it has been demonstrated that miRNAs play a regulatory role in the pathogenesis of lupus. Therefore, dysregulated miRNAs can be considered as promising diagnostic biomarkers for lupus. This article is an overview of lupus-related miRNA profiling studies and arrays in the Gene Expression Omnibus (GEO) database. The aims of our study were to widen current knowledge of known dysregulated miRNAs as potential biomarkers of SLE and to introduce a bioinformatics approach to using microarray data and finding novel miRNA and gene candidates for further study. We identified hsa-miR-4709-5p, hsa-miR-140, hsa-miR-145, hsa-miR-659, hsa-miR-134, hsa-miR-150, hsa-miR-584, hsa-miR-409 and hsa-miR-152 as potential biomarkers by integrated bioinformatics analysis.
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