[Toll-like receptor 4 in liver ischemia-reperfusion injury].

Toll-like receptor 4 (TLR4) is a member of the toll-like receptor family and belongs to the family of pattern recognition receptors. The role of TLR4 signaling pathway in liver ischemia-reperfusion injury has been widely studied in recent years, and its control methods in inflammatory response is becoming the most important research hotspot. In this paper, the research progress of the molecules and their regulatory mechanisms involved with TLR4 signaling pathway in liver ischemia-reperfusion injury is reviewed, which act as a new foundation of clinical research to study the pathogenic mechanisms and treatment plan.Toll样受体（TLR）4是TLRs家族中的一员，属于模式识别受体家族。近年来，TLR4信号通路在肝缺血再灌注损伤中的作用被广泛研究，成为炎症反应及其控制手段最重要的研究热点。文中就TLR4信号通路在肝缺血再灌注损伤中参与的分子及其调控机制的研究进展进行综述介绍，为研究临床肝缺血再灌注损伤的发生机制及其治疗方案提供新的依据。.