癌症
癌变
转移
泛素
乳腺癌
癌细胞
癌症研究
下调和上调
生物
功能(生物学)
生物信息学
生物化学
细胞生物学
遗传学
基因
作者
Senfeng Xiang,Xuejing Shao,Ji Cao,Bo Yang,Qiaojun He,Xuejing Shao
出处
期刊:Current Molecular Pharmacology
[Bentham Science]
日期:2019-11-15
卷期号:13 (3): 182-191
被引量:18
标识
DOI:10.2174/1874467212666191113130312
摘要
Posttranslational protein modifications are known to be extensively involved in cancer, and a growing number of studies have revealed that the ubiquitin-like modifier FAT10 is directly involved in cancer development. FAT10 was found to be highly upregulated in various cancer types, such as glioma, hepatocellular carcinoma, breast cancer and gastrointestinal cancer. Protein FAT10ylation and interactions with FAT10 lead to the functional change of proteins, including proteasomal degradation, subcellular delocalization and stabilization, eventually having significant effects on cancer cell proliferation, invasion, metastasis and even tumorigenesis. In this review, we summarized the current knowledge on FAT10 and discussed its biological functions in cancer, as well as potential therapeutic strategies based on the FAT10 pathway.
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