A retrospective study of OSF coexisted with OLK or OLP

Objective To analyze the clinical feature and pathological characteristics of oral submucous fibrosis (OSF) coexisted with oral leukoplakia (OLK) or oral lichen planus (OLP), and summarize both the common and each clinical and pathological characteristics of two kinds of diseases. Methods The clinical and pathological data of 74 patients with OSF coexisted with OLK and 57patients with OSF coexisted with OLP were retrospectively reviewed. Results Most of patients with OSF coexisted with OLK or OLP were mainly young and middle-aged male patients, and all had the habit of eating betel quid chewing. Most of them had the habit of smoking and alcohol drinking; while their limitation of mouth opening were not obvious. Patients coexisted with unilateral OLK or OLP all had a unilateral mastication of chewing betel nut; the prevalence rate of erosive OLP was lower in the patients with OSF coexisted OLP than that of OLP patients never chew betel nut. The pathology of both OSF coexisted with OLK or OLP was with the respective characteristics of OLK or OLP on the basis of OSF, and the epithelium was thickened more than atrophic. No relationship was found between the degree of epithelial hyperplasia and the severity of fibrosis in patients with OSF coexisted with OLK. Conclusions OSF coexisted with OLK and OSF coexisted with OLP were the occurrence of OLK or OLP on the basis of OSF, which were not a simple superposition of two diseases, but combination with their own characteristics of OSF coexisted with OLK or OLP. Key words: Oral submucous fibrosis/CO; Leukoplakia, oral/CO; Lichen planus, oral/CO