Apios americana Medik flowers polysaccharide (AFP) alleviate Cyclophosphamide-induced immunosuppression in ICR mice

免疫抑制 免疫系统 环磷酰胺 免疫学 多糖 生物 免疫 细胞因子 造血 化疗 干细胞 生物化学 细胞生物学 遗传学
作者
Qiang Chu,Yiru Zhang,Wen Chen,Ruoyi Jia,Xin Yu,Yaxuan Wang,Yonglu Li,Yangyang Liu,Xiang Ye,Lushuang Yu,Xiaodong Zheng
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:144: 829-836 被引量:46
标识
DOI:10.1016/j.ijbiomac.2019.10.035
摘要

Immunosuppression refers to the suppression of the immune response. The immune function of immunocompromised people is not enough to resist bacterial, viral, fungal and other infections, leading to a series of diseases. A large number of experimental data show that polysaccharide compounds are immune modulators, which can enhance the body immunity with little toxic. Meanwhile, it can reduce the side effects of commonly used immunosuppressants, such as cytotoxicity, decreased ability of the body to fight infection, and inhibition of the reproduction of bone marrow hematopoietic cells. It can be used as oral or injectable drugs. In this study, a purified polysaccharide was primarily extracted from the flowers of Apios americana Medik (AAM), which can improve the immunosuppression induced by cyclophosphamide (CTX). The immunoenhancement effect of AFP was evaluated by measuring the body weight, immune organ index, cytokine secretion and antibody generated levels of CTX-induced mice. Our results showed that AFP could significantly improve the above immune indexes, which indicated AFP could alleviate immunosuppression induced by CTX. The study provided a theoretical basis for the promotion, development and application of AAM as a newly introduced food material.
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