神经活性类固醇
激素
神经系统
类固醇
类固醇激素
中枢神经系统
性类固醇
生物
内分泌学
内科学
神经科学
医学
受体
γ-氨基丁酸受体
作者
Silvia Giatti,Silvia Diviccaro,Melania Maria Serafini,Donatella Caruso,Luis Miguel García‐Segura,Barbara Viviani,Roberto Cosimo Melcangi
标识
DOI:10.1016/j.yfrne.2019.100804
摘要
The nervous system, in addition to be a target for steroid hormones, is the source of a variety of neuroactive steroids, which are synthesized and metabolized by neurons and glial cells. Recent evidence indicates that the expression of neurosteroidogenic proteins and enzymes and the levels of neuroactive steroids are different in the nervous system of males and females. We here summarized the state of the art of neuroactive steroids, particularly taking in consideration sex differences occurring in the synthesis and levels of these molecules. In addition, we discuss the consequences of sex differences in neurosteroidogenesis for the function of the nervous system under healthy and pathological conditions and the implications of neuroactive steroids and neurosteroidogenesis for the development of sex-specific therapeutic interventions.
科研通智能强力驱动
Strongly Powered by AbleSci AI