成纤维细胞
衰老
细胞生物学
细胞外基质
结缔组织
促炎细胞因子
真皮成纤维细胞
表型
皮肤老化
生物
细胞外
免疫学
医学
炎症
细胞培养
遗传学
皮肤病科
基因
作者
Meinhard Wlaschek,Pallab Maity,Evgenia Makrantonaki,Karin Scharffetter‐Kochanek
标识
DOI:10.1016/j.jid.2020.11.010
摘要
There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately remove senescent (SEN) fibroblasts from tissues. SEN fibroblasts by the release of the proinflammatory, tissue degrading senescent-associated secretory phenotype factors and vesicles with distinct cargo impact on their endogenous niche and spread senescence and skin aging. In this review, we will further discuss less noticed facets, including the plasticity of distinct dermal fibroblast phenotypes, the underestimated impact of the extracellular matrix itself, and the depletion of fibroblast subsets on skin homeostasis and aging.
科研通智能强力驱动
Strongly Powered by AbleSci AI