The Role of Chemotherapy in Extraskeletal Osteosarcoma: A Propensity Score Analysis of the Surveillance Epidemiology and End Results (SEER) Database.

骨肉瘤 流行病学 回顾性队列研究 生存分析 癌症 危险系数 人口 外科 肉瘤 化疗 入射(几何) 多元分析
作者
Lin Qi,Lu Wan,Xiaolei Ren,Wenchao Zhang,Chao Tu,Zhihong Li
出处
期刊:Medical Science Monitor [International Scientific Information Inc.]
卷期号:26 被引量:2
标识
DOI:10.12659/msm.925107
摘要

BACKGROUND Incidence of extraskeletal osteosarcoma (ESOS) is extremely low and the prognosis remains unclear. We conducted this study to explore prognostic factors and the role of chemotherapy in ESOS. MATERIAL AND METHODS We screened data from the Surveillance Epidemiology and End Results (SEER) database (1975-2016). Three hundred ten patients with ESOS were included and 49.4% (107/310) of them underwent chemotherapy. We performed logistic regression analysis to investigate potential factors determining selection of chemotherapy. An inverse probability of treatment weighting (IPTW) and propensity score matching (PSM)-adjusted Kaplan-Meier curve was created and log-rank test and Cox regression analysis were performed to compare overall survival (OS) and cancer-specific survival (CSS) in patients treated with and without chemotherapy. Subgroup analysis also was conducted based on age, tumor site, stage, size, and surgery. RESULTS Chemotherapy in ESOS was not associated with improved OS in the unmatched cohort (HR, 0.764; 95% CI, 0.555-1.051; p=0.098). The insignificant treatment effect of chemotherapy was also noted in IPTW-adjusted (HR, 0.737; 95% CI, 0.533-1.021; p=0.066) and PSM-adjusted (HR, 0.804; 95% CI, 0.552-1.172; p=0.257) Cox regression analysis. The insignificant treatment effect was consistent across all subgroups and there was no significant heterogeneity of chemotherapy effect (all p for interaction >0.05). CONCLUSIONS The study suggested that chemotherapy has no significant benefit on prognosis of patients with ESOS. These findings should be considered when making treatment decisions about patients with ESOS.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
栗子完成签到 ,获得积分10
1秒前
等待的盼波完成签到,获得积分10
1秒前
CAOHOU应助嘟嘟请让一让采纳,获得10
1秒前
1秒前
天天向上完成签到,获得积分10
1秒前
野原小龙虾完成签到,获得积分10
2秒前
time完成签到,获得积分10
2秒前
2秒前
阿绿发布了新的文献求助10
6秒前
7秒前
7秒前
雨柏完成签到 ,获得积分10
7秒前
wanci应助qwe1108采纳,获得10
8秒前
明天过后完成签到,获得积分10
10秒前
jin完成签到,获得积分10
11秒前
yhy完成签到 ,获得积分10
12秒前
黑色卡布奇诺完成签到,获得积分20
12秒前
tanglu发布了新的文献求助10
12秒前
可爱的函函应助梁大海采纳,获得10
12秒前
成就绮琴完成签到 ,获得积分10
13秒前
xicifish完成签到,获得积分10
13秒前
目光之澄完成签到,获得积分10
14秒前
wanci应助研友_ndDPBn采纳,获得10
14秒前
耍酷的白梦完成签到,获得积分10
15秒前
miracle完成签到 ,获得积分10
16秒前
coding完成签到,获得积分10
17秒前
18秒前
犹豫水蓝完成签到,获得积分10
19秒前
yin完成签到,获得积分10
19秒前
JUGG完成签到,获得积分10
19秒前
CipherSage应助阿湫采纳,获得10
20秒前
FIN应助手机采纳,获得20
20秒前
星辰大海应助东黎采纳,获得10
20秒前
量子星尘发布了新的文献求助10
20秒前
wujingshuai完成签到,获得积分10
21秒前
少年完成签到,获得积分10
21秒前
星辰大海应助ficus_min采纳,获得10
22秒前
小柒柒完成签到,获得积分10
23秒前
sdfwsdfsd完成签到,获得积分10
24秒前
亮仔完成签到,获得积分10
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038524
求助须知:如何正确求助?哪些是违规求助? 3576221
关于积分的说明 11374737
捐赠科研通 3305912
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892688
科研通“疑难数据库(出版商)”最低求助积分说明 815048