化学
体内
体外
动力学
吸收(声学)
药理学
生物化学
医学
生物
材料科学
生物技术
物理
量子力学
复合材料
出处
期刊:PubMed
日期:1980-05-01
卷期号:40 (5): 1519-24
被引量:91
摘要
Through an in vivo and in vitro analysis of the absorption kinetics of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) in the normal tissues and solid tumors of mice, rats, and rabbits, it has been demonstrated that normal tissues actively concentrate WR-2721 against a concentration gradient, whereas solid tumors passively absorb it, or, if active concentration of WR-2721 is present in tumors, it operates at a far reduced rate relative to normal tissues. These observations can account for the ability of WR-2721 to selectively protect normal tissues against both radiation and alkylating agent injury.
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