牙龈卟啉单胞菌
牙周炎
效价
医学
慢性牙周炎
抗体效价
免疫学
抗体
免疫球蛋白G
内科学
作者
Chieko Kudo,Koji Naruishi,Hiroshi Maéda,Yoshimitsu Abiko,Takamune Hino,M. Iwata,C. Mitsuhashi,Shinya Murakami,Toshiyuki Nagasawa,Toshihiko Nagata,S. Yoneda,Yoshiaki Nomura,T. Noguchi,Yukihiro Numabe,Yorimasa Ogata,Tsutomu Sato,Hidetoshi Shimauchi,Kazuhisa Yamazaki,Atsutoshi Yoshimura,Shogo Takashiba
标识
DOI:10.1177/0022034512461796
摘要
Chronic periodontitis is a silent infectious disease prevalent worldwide and affects lifestyle-related diseases. Therefore, efficient screening of patients is essential for general health. This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens. Oral examination was performed, and IgG titers against periodontal pathogens were measured by ELISA in 1,387 individuals. The cut-off value of the IgG titer was determined in receiver operating characteristic curve analysis, and changes in periodontal clinical parameters and IgG titers by periodontal treatment were evaluated. The relationships between IgG titers and severity of periodontitis were analyzed. The best cut-off value of IgG titer against Porphyromonas gingivalis for screening periodontitis was 1.682. Both clinical parameters and IgG titers decreased significantly under periodontal treatment. IgG titers of periodontitis patients were significantly higher than those of healthy controls, especially in those with sites of probing pocket depth over 4 mm. Multiplied cut-off values were useful to select patients with severe periodontitis. A blood IgG antibody titer test for Porphyromonas gingivalis is useful to screen hitherto chronic periodontitis patients (ClinicalTrials.gov number NCT01658475).
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