阳离子聚合
肺表面活性物质
胶束
等温微量热法
膜
Zeta电位
化学
材料科学
有机化学
生物物理学
水溶液
生物化学
纳米颗粒
纳米技术
焓
生物
物理
量子力学
作者
Chengcheng Zhou,Fengyan Wang,Hui Chen,Meng Li,Fulin Qiao,Zhang Liu,Yanbo Hou,Chunxian Wu,Yaxun Fan,Libing Liu,Shu Wang,Yilin Wang
标识
DOI:10.1021/acsami.5b12688
摘要
This work reports that cationic micelles formed by cationic trimeric, tetrameric, and hexameric surfactants bearing amide moieties in spacers can efficiently kill Gram-negative E. coli with a very low minimum inhibitory concentration (1.70-0.93 μM), and do not cause obvious toxicity to mammalian cells at the concentrations used. With the increase of the oligomerization degree, the antibacterial activity of the oligomeric surfactants increases, i.e., hexameric surfactant > tetrameric surfactant > trimeric surfactant. Isothermal titration microcalorimetry, scanning electron microscopy, and zeta potential results reveal that the cationic micelles interact with the cell membrane of E. coli through two processes. First, the integrity of outer membrane of E. coli is disrupted by the electrostatic interaction of the cationic ammonium groups of the surfactants with anionic groups of E. coli, resulting in loss of the barrier function of the outer membrane. The inner membrane then is disintegrated by the hydrophobic interaction of the surfactant hydrocarbon chains with the hydrophobic domains of the inner membrane, leading to the cytoplast leakage. The formation of micelles of these cationic oligomeric surfactants at very low concentration enables more efficient interaction with bacterial cell membrane, which endows the oligomeric surfactants with high antibacterial activity.
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