Association of Age at Menopause and Duration of Reproductive Period With Depression After Menopause

更年期 萧条(经济学) 医学 更年期 优势比 观察研究 心情 外科更年期 荟萃分析 精神科 人口学 内科学 宏观经济学 社会学 经济
作者
Marios K. Georgakis,Thomas Thomopoulos,Andreas-Antonios Diamantaras,Eleni Ι. Kalogirou,Alkistis Skalkidou,Stella S. Daskalopoulou,Eleni Petridou
出处
期刊:JAMA Psychiatry [American Medical Association]
卷期号:73 (2): 139-139 被引量:142
标识
DOI:10.1001/jamapsychiatry.2015.2653
摘要

Importance

Estrogens have neuroprotective and antidepressive effects; however, associations between indices of reduced endogenous estrogens and risk for postmenopausal depression have not been systematically explored.

Objective

To investigate the association of age at menopause and the duration of the reproductive period with the risk for depression among postmenopausal women with naturally occurring menopause.

Data Sources

A search strategy for use of MEDLINE was developed (through January 1, 2015) using the key termsmenopause,climacteric,reproductive period,depression, andmood disorders. References of included studies and reviews were also screened; authors were contacted to maximize synthesized evidence.

Study Selection

A total of 12 323 articles, without language restriction, were screened by pairs of reviewers to identify observational studies related to the study hypothesis; 14 studies were eligible for meta-analysis.

Data Extraction and Synthesis

Pairs of reviewers independently extracted information on study design and type of analysis by participants’ characteristics and methods of depression ascertainment. Study quality was assessed using the Newcastle-Ottawa Scale, and fixed- or random-effects models were implemented.

Main Outcomes and Measures

Pooled-effect estimates for depression, defined by psychiatric evaluation or validated instruments, by age at menopause and duration of the reproductive period.

Results

The 14 studies included in the meta-analysis represented 67 714 women. An inverse association (reported as odds ratio [OR]; 95% CI of 2-year increments) with depression in postmenopausal women was shown for increasing age at menopause (0.98; 0.96-0.99 [67 434 unique participants; 13 studies]) and duration of the reproductive period (0.98; 0.96-0.99 [54 715 unique participants; 5 studies]). Menopause at age 40 or more years compared with premature menopause was associated with a 50% decreased risk for depression (3033 unique participants; 4 studies). Pooling of studies examining severe depression showed a 5% decrease in risk of severe depression with increasing (2-year increment) age at menopause (52 736 unique participants; 3 studies); sensitivity analysis of studies controlling for past depression revealed similar results for age at menopause (0.98; 0.96-1.00 [48 894 unique participants; 3 studies). No heterogeneity or publication bias was evident in the main analyses.

Conclusions and Relevance

Longer exposure to endogenous estrogens, expressed as older age at menopause and longer reproductive period, is associated with a lower risk of depression in later life. Identifying women at higher risk for depression due to early menopause who could benefit from psychiatric intervention or estrogen-based therapies could be useful in the clinical setting.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
宇宙中的先行者完成签到,获得积分10
刚刚
朴实的小萱完成签到 ,获得积分10
刚刚
zyt完成签到,获得积分10
刚刚
JJ完成签到,获得积分10
1秒前
666发布了新的文献求助10
1秒前
东方雨季完成签到,获得积分10
1秒前
希望天下0贩的0应助猫猫采纳,获得10
1秒前
luoziwuhui完成签到,获得积分10
2秒前
2秒前
2秒前
华仔应助落微采纳,获得10
2秒前
CyrusSo524应助焱垚采纳,获得10
2秒前
3秒前
给我个二硫碘化钾完成签到,获得积分10
3秒前
3秒前
葛怀锐完成签到 ,获得积分10
3秒前
ada完成签到,获得积分10
4秒前
tian完成签到,获得积分10
4秒前
叶子完成签到,获得积分10
4秒前
4秒前
唐若冰完成签到,获得积分10
5秒前
frx1996完成签到,获得积分20
5秒前
小二郎应助front采纳,获得10
5秒前
伶俐妙海应助忐忑的远山采纳,获得40
5秒前
科研通AI2S应助zzs喵采纳,获得10
5秒前
5秒前
whitedawn完成签到 ,获得积分10
5秒前
隐形惜筠完成签到 ,获得积分10
6秒前
姜水完成签到,获得积分10
6秒前
叶子阳完成签到 ,获得积分10
6秒前
7秒前
7秒前
7秒前
权翼完成签到,获得积分10
7秒前
Orange应助郑昕玥采纳,获得10
7秒前
耍酷曼雁发布了新的文献求助30
8秒前
sj090完成签到,获得积分10
8秒前
8秒前
SYLH应助Loik采纳,获得10
8秒前
8秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968844
求助须知:如何正确求助?哪些是违规求助? 3513769
关于积分的说明 11169920
捐赠科研通 3249095
什么是DOI,文献DOI怎么找? 1794630
邀请新用户注册赠送积分活动 875278
科研通“疑难数据库(出版商)”最低求助积分说明 804755