丝素
自愈水凝胶
组织工程
丝绸
生物材料
生物相容性
材料科学
丝胶
家蚕
生物医学工程
再生医学
再生(生物学)
纳米技术
化学
复合材料
高分子化学
细胞
生物化学
工程类
冶金
细胞生物学
生物
基因
作者
Yihan Lyu,Yusheng Liu,H.-Y. He,Hongmei Wang
出处
期刊:Gels
[MDPI AG]
日期:2023-05-22
卷期号:9 (5): 431-431
被引量:6
摘要
Silk fibroin (SF) is an excellent protein-based biomaterial produced by the degumming and purification of silk from cocoons of the Bombyx mori through alkali or enzymatic treatments. SF exhibits excellent biological properties, such as mechanical properties, biocompatibility, biodegradability, bioabsorbability, low immunogenicity, and tunability, making it a versatile material widely applied in biological fields, particularly in tissue engineering. In tissue engineering, SF is often fabricated into hydrogel form, with the advantages of added materials. SF hydrogels have mostly been studied for their use in tissue regeneration by enhancing cell activity at the tissue defect site or counteracting tissue-damage-related factors. This review focuses on SF hydrogels, firstly summarizing the fabrication and properties of SF and SF hydrogels and then detailing the regenerative effects of SF hydrogels as scaffolds in cartilage, bone, skin, cornea, teeth, and eardrum in recent years.
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