赫拉
Zeta电位
动态光散射
纳米载体
纳米颗粒
超顺磁性
化学
流式细胞术
右旋糖酐
氧化铁纳米粒子
分散性
纳米技术
核化学
材料科学
色谱法
细胞
高分子化学
免疫学
医学
生物化学
物理
磁场
量子力学
磁化
作者
Farah Shamil Abdulwahid,Adawiya J. Haider,Sharafaldin Al-Musawi
标识
DOI:10.1088/2043-6262/aca606
摘要
Abstract The dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) grafted with foliate (FA) were prepared and used as a nanocarrier for ellipticine (ET) delivery in cervical cancer. In this work we prepared superparamagnetic iron oxide nanoparticles by pulsed laser ablation in liquid method. The formation of the SPION@DEX-ET-FA nanosystem was performed by a reverse microemulsion process. Dynamic light scattering (DLS), atomic force microscopy (AFM), and field emission scanning electron microscope (FESEM) were used to characteristic the morphological properties of the NPs. The appropriate impact of a therapeutic dose of SPION@DEX-ET-FA on both cancer and healthy cell lines was estimated using a 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay. The flow cytometry assays was used to evaluate the induction of apoptosis in Hela cervical cancer cells. The findings of the SPION@DEX-ET-FA formulated were spherical particles with an average size, polydispersity and a zeta potential of 101 ± 15.02 nm, 0.075 and −33.8 mV, respectively. The nanosystem displayed dose-dependent cytotoxic effects on Hela cells. The results showed that SPION@DEX-ET-FA retained antitumor activity and no adverse effects on healthy cells were found.
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