Comparative efficacy of tonifying kidney on treatment of mammary gland hyperplasia: Systematic review with network meta-analysis

Network meta-analysis is used as a data synthesizer, incorporating direct and indirect evidence about treatments in a series of randomized control trials. To evaluate the comparative efficacy of various Kidney nourishments for treating mammary gland hyperplasia (HMG). We performed a network meta-analysis to combine direct and indirect data to investigate the efficiency of drug therapies, which were evaluated in relevant randomized control trials for HMG. Thirty-seven eligible studies were included in this meta-analysis. A total of 4002 patients were included, in whom 21 therapeutic interventions were used. BieJiaJain Pill showed the highest efficacy in total efficiency, whereas Tamoxifen was the least effective. YanLuRuKang Capsule/Pill, AnRu Decoction showed higher efficacy in modulating Estradiol, whereas Tamoxifen and RuPiSanJie Capsule were lower effective. YanLuRuKang Capsule/Pill, RuKangShu Capsule, AnRu Decoction showed higher efficacy in narrowing lump, whereas RuKang Pill/Capsule, RuPiXiao Granules/Pill, RuPiSanJie Capsule were lower effective. YiShenShuGan Capsule/Decoction, WenYangXiaoPi Compound, TiaoChongGuBen Decoctiom showed higher efficacy in reducing painscore, whereas Tamoxifen, RuPiXiao Granules/Pill, RuPiSanJie Capsule were lower effective. XiaoYao Pill, RuPiSanJie Capsule showed higher efficacy in modulating progesterone, whereas WenYangXiaoPi Compound, TiaoChongGuBen Decoctiom were poorly effective. YiShenShuGan Capsule/Decoction, WenYangXiaoPi Compound, AnRu Decoction showed higher efficacy in modulating prolactin, whereas Tamoxifen, RuPiXiao Granules/Pill, RuPiSanJie Capsule were lower effective. In this study, the efficacy of oral Chinese herbal compounds in treating mammary glands hyperplasia was analyzed systematically and objectively, which provided a theoretical basis for clinical medication and was helpful for clinicians to make the best choice of medication. Due to the limitations of the selected literature, the conclusions of this study still need to be validated by high-quality clinical trial studies.