Comparison of localization methods for 3D Super-Resolution Ultrasound Imaging

Super-Resolution (SR) ultrasound (US) imaging can overcome the wave diffraction limit and reveal detailed microvas-culature. Localization methods including Gaussian fitting, cross-correlation, and centroid detection have been investigated in 2D SR US imaging. With the increasing demand for volumetric information, this study aims to compare the performance of centroid detection and 3D normalized cross-correlation (NCC) in 3D SR US.