多神经根神经病
格林-巴利综合征
医学
免疫学
神经炎
免疫系统
抗原
自身免疫
发病机制
精神科
作者
Pamela McCombe,Todd A. Hardy,Robert J. Nona,Judith M. Greer
标识
DOI:10.3389/fimmu.2022.1038411
摘要
Guillain Barré syndrome (GBS) and its variants, and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP and its variants, are regarded as immune mediated neuropathies. Unlike in many autoimmune disorders, GBS and CIDP are more common in males than females. Sex is not a clear predictor of outcome. Experimental autoimmune neuritis (EAN) is an animal model of these diseases, but there are no studies of the effects of sex in EAN. The pathogenesis of GBS and CIDP involves immune response to non-protein antigens, antigen presentation through non-conventional T cells and, in CIDP with nodopathy, IgG4 antibody responses to antigens. There are some reported sex differences in some of these elements of the immune system and we speculate that these sex differences could contribute to the male predominance of these diseases, and suggest that sex differences in peripheral nerves is a topic worthy of further study.
科研通智能强力驱动
Strongly Powered by AbleSci AI