小檗碱
多囊卵巢
不育
生殖医学
排卵
医学
生殖系统
卵巢
怀孕
女性生殖系统
内分泌学
胰岛素抵抗
内科学
生物
肥胖
激素
药理学
遗传学
作者
Qing Xia,Wenjing Wang,Zijie Liu,Jiaying Xiao,Cong Qiao,Yu Zhao,Bowen Li,Yuanli Liu,Yahui Peng,Xinyu Yang,Jiabin Shi,Qing Xia,Dayong Wang
标识
DOI:10.1016/j.ejphar.2022.175433
摘要
Polycystic ovary syndrome (PCOS) is a complex reproductive disorder that seriously harms female reproductive health and decreases quality of life. Although spontaneous or assisted ovulation occurs, women with PCOS suffer from poor-quality oocytes and embryos and lower fertilization and final pregnancy rates. Therefore, it is urgent to identify new pathological mechanisms and discover the underlying therapeutic targets for reproductive disorders associated with PCOS. Berberine, one of the famous traditional Chinese medicines, has been shown to improve ovulation and live birth rates in women with PCOS. The effects of berberine on insulin resistance and abnormal glucose and lipid metabolism for restoring the reproductive health of women with PCOS are well recognized and have been widely studied, but much less attention has been given to its anti-inflammatory properties. Chronic low-grade inflammation is the unifying feature of PCOS and may contribute to reproductive disorders in PCOS. Berberine can modulate the inflammatory state of the ovaries and uterus in PCOS. The anti-inflammatory properties of berberine may provide new insight into the mechanisms by which berberine alleviates reproductive disorders associated with PCOS. Here, we summarized the most recent insights into the anti-inflammatory properties of berberine in PCOS reproductive disorders to inspire researchers to pursue new study directions involving berberine.
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