Inside Front Cover: Tandem‐Controlled Dynamic DNA Assembly Enables Temporally‐Selective Orthogonal Regulation of cGAS–STING Stimulation

Spatiotemporally controlled orthogonal regulation of cGAS–STING stimulation has been achieved in the Research Article (e202417916) by Xiangfei Li, Fangzhi Yu and Lele Li. In the approach, enzyme-triggered DNA assembly allows the cGAS–STING stimulation, while light-induced fragmentation of the double-stranded DNA enables termination of such stimulation, thereby achieving orthogonal control over the immune regulation.