Potential of Histone Deacetylase 6 Inhibitors as a Treatment of Neurodegenerative Diseases

The invention in this patent application relates to 2-substituted-6-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)isoindolin-1-one derivatives represented herein by formula 1. These compounds possess HDAC6 inhibitory activity and may be useful for the treatment of central nervous system diseases including neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy.