Glycerolipids disrupt regulatory T-cells in asthma

Asthma is a chronic inflammatory disease that arises due to an exacerbated immune response causing narrowing and hypersensitivity of the airways [1]. The full aetiology of asthma is not fully understood; however, several studies have shown the role of genetic, immunological and environmental factors in its development or severity. Asthma remains a significant health challenge, contributing to substantial morbidity and, in some instances, mortality. Therefore, it is crucial to enhance our understanding of this condition and to identify new biomarkers. From an immunological point of view, different cell types, such as T-cells, mast cells and eosinophils, play a crucial role in disease induction or exacerbation [2]. T-cells, in particular Th2 and Th17 cells, have been shown to be involved in promoting asthma severity by promoting the recruitment of immune cells, such as eosinophils and neutrophils, respectively [3, 4].