An Antibacterial and Antioxidant Food Packaging Film Based on Amphiphilic Polypeptides‐Resveratrol‐Chitosan

Abstract Antimicrobial and antioxidant packaging films play a crucial role in extending food shelf life, maintaining quality, and enhancing safety by inhibiting microbial growth and slowing oxidation processes. However, most commercial preservative films suffer from limited antimicrobial and antioxidant properties. Moreover, these films are made from petroleum‐based materials that degrade into microplastics, resulting in environmental contamination and potential health risks for humans. Herein, an antibacterial and antioxidant food packaging film (CS‐SAP@R) is developed by integrating star‐shaped amphiphilic polypeptides (SAP) and resveratrol (R) into the chitosan (CS) matrix. The incorporation of SAP not only effectively addresses the existing compatibility issues between the highly hydrophobic resveratrol and water‐soluble CS film, but also significantly enhances the antimicrobial properties of CS. Additionally, the well‐integrated resveratrol molecules endow the film with superior antioxidant properties. Furthermore, CS‐SAP@R has achieved bacterial killing rates of 97.31% against E. coli and 99.05% against S. aureus . The enhanced characteristics of the CS‐SAP@R film contribute to its exceptional preservation performance, effectively extending the shelf life of perishable products by ≈3 days when stored at 4 °C. These remarkable attributes underscore the benefits of polypeptide‐based biopolymers and demonstrate the potential applicability of the CS‐SAP@R film in effectively safeguarding perishable products.