生物
基因组
拷贝数变化
适应(眼睛)
非整倍体
遗传学
基因组大小
表型可塑性
进化生物学
抗真菌药
倍性
计算生物学
表型
基因
染色体
白色念珠菌
神经科学
作者
Petra Vande Zande,Xin Zhou,Anna Selmecki
出处
期刊:Annual Review of Microbiology
[Annual Reviews]
日期:2023-06-12
卷期号:77 (1)
标识
DOI:10.1146/annurev-micro-041320-112443
摘要
Fungal species have dynamic genomes and often exhibit genomic plasticity in response to stress. This genome plasticity often comes with phenotypic consequences that affect fitness and resistance to stress. Fungal pathogens exhibit genome plasticity in both clinical and agricultural settings and often during adaptation to antifungal drugs, posing significant challenges to human health. Therefore, it is important to understand the rates, mechanisms, and impact of large genomic changes. This review addresses the prevalence of polyploidy, aneuploidy, and copy number variation across diverse fungal species, with special attention to prominent fungal pathogens and model species. We also explore the relationship between environmental stress and rates of genomic changes and highlight the mechanisms underlying genotypic and phenotypic changes. A comprehensive understanding of these dynamic fungal genomes is needed to identify novel solutions for the increase in antifungal drug resistance. Expected final online publication date for the Annual Review of Microbiology, Volume 77 is September 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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