化学
炔烃
组合化学
酰胺
有机合成
有机化学
催化作用
作者
Jian Lei,Xiaolan Xie,Na Hou,Lin Yang
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2023-05-31
摘要
Abstract Ynamides are versatile reactive building blocks in organic chemistry; consequently, synthetic methodologies to fabricate these compounds have received extensive attention. The construction of a C–N bond between an alkyne surrogate and an amide is a powerful and practical way to access ynamides, and has been widely studied. Recently, the amidation of terminal alkynes has emerged as a straightforward alternative. This Synpacts article briefly summarizes the use of C(sp)–H amidation strategies to form ynamides; it also highlights our recent work on the synthesis of ynehydrazides through the copper-catalyzed addition of terminal alkynes to dialkyl azodicarboxylates. Finally, some future directions in this field are outlined.
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