医学
电针
眼科
眼泪
透明质酸钠
人造眼泪
随机对照试验
内科学
针灸科
外科
病理
替代医学
作者
Guang Yang,Xiehe Kong,Xiaocong Guo,Yong‐Lu Yang,Chen Xie,Yunqiong Lu,Jie Liu,Huangan Wu,Dan Zhang,Yuelan Zou,Cuihong Zhang,Hong. Jun-hee,Xiao-peng Ma
摘要
The purpose of the study was to assess the efficacy of electroacupuncture on dry eye (DE).Eighty-four DE patients were randomly assigned to receive electroacupuncture (EAG) three times a week or 0.1% sodium hyaluronate artificial tears (ATG) four times per day for 4 weeks. The primary outcomes were non-invasive tear film breakup time (NIBUT) and tear meniscus height (TMH). The secondary outcomes included the ocular surface disease index (OSDI), Schirmer I test (SIT), corneal sodium fluorescein staining (CFS) score, corneal topography descriptors surface asymmetry index (SAI) and surface regularity index (SRI), corneal sensitivity, 36-item Short-form Health Survey (SF-36) score and Hospital Anxiety and Depression Scale (HADS) score. All outcomes were assessed at Week 0 (baseline), Week 4 (after-treatment) and Week 8 (follow-up).Between-group comparisons showed significant differences in the changes in NIBUT (Week 4, p = 0.003; Week 8, p = 0.008), TMH (Week 4, p = 0.014; Week 8, p = 0.009), OSDI (Week 4, p = 0.029; Week 8, p = 0.022), CFS score (Week 8, p = 0.036) and SF-36 role-physical score (Week 4, p = 0.010), favouring EAG. Mean changes in SIT, SAI, SRI, corneal sensitivity and HADS scores were statistically equal between the two groups (all p > 0.05). Treatment with electroacupuncture was well-tolerated and showed minimal adverse events.Compared with artificial tears, electroacupuncture shows superior efficacy in improving tear film stability and symptoms of DE.
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