Catalyst‐Free Indirect C−F Activation of 3‐Perfluoroalkyl Indoles

We present a catalyst-free method for indirect C−F activation of a perfluorinated side chain in C(3) position of 1H-indoles with moderate to good yields, which allows the introduction of a nucleophile at the α-CF2-group of the perfluorinated chain. By adapting this approach, it is also possible to modify 3-perfluorobutyl-2-phenyl-1H-indole to generate privileged structures for medicinal chemistry.