化脓性链球菌
入射(几何)
法定传染病
抗生素耐药性
红霉素
人口
克林霉素
医学
公共卫生
疾病控制
疾病
兽医学
抗生素
微生物学
生物
内科学
环境卫生
病理
金黄色葡萄球菌
细菌
物理
光学
遗传学
作者
Alyssa Golden,Averil Griffith,Walter Demczuk,Gregory J. Tyrrell,Julianne V. Kus,Allison McGeer,Marc-Christian Domingo,Linda Hoang,Jessica Minion,Paul Van Caeseele,Hanan Smadi,David Haldane,George Zahariadis,Kristen Mead,Laura Steven,Lori Strudwick,Anita Li,Michael R. Mulvey,Irene Martín
出处
期刊:Canada communicable disease report
[Infectious Disease and Control Branc (IDPCB) - Public Health Agency of Canada]
日期:2022-09-20
卷期号:48 (9): 407-414
被引量:3
标识
DOI:10.14745/ccdr.v48i09a05
摘要
Invasive group A streptococcal (iGAS) disease (caused by Streptococcus pyogenes) has been a nationally notifiable disease in Canada since 2000. This report summarizes the demographics, emm types and antimicrobial resistance of iGAS infections in Canada in 2020.The Public Health Agency of Canada's National Microbiology Laboratory (Winnipeg, Manitoba) collaborates with provincial and territorial public health laboratories to conduct national surveillance of invasive S. pyogenes. Emm typing was performed on all isolates using the Centers for Disease Control and Prevention emm sequencing protocol. Antimicrobial susceptibilities were determined using Kirby-Bauer disk diffusion according to Clinical and Laboratory Standards Institute guidelines. Population-based iGAS disease incidence rates up to 2019 were obtained through the Canadian Notifiable Disease Surveillance System.Overall, the incidence of iGAS disease in Canada has increased from 4.0 to 8.1 cases per 100,000 population from 2009 to 2019. The 2019 incidence represents a slight decrease from the 2018 rate of 8.6 cases per 100,000 population. A total of 2,867 invasive S. pyogenes isolates that were collected during 2020 are included in this report, representing a decrease from 2019 (n=3,194). The most common emm types in 2020 were emm49 (16.8%, n=483) and emm76 (15.0%, n=429), both increasing significantly in prevalence since 2016 (p<0.001). The former most prevalent type, emm1, decreased to 7.6% (n=217) in 2020 from 15.4% (n=325) in 2016. Antimicrobial resistance rates in 2020 included 11.5% resistance to erythromycin, 3.2% resistance to clindamycin and 1.6% nonsusceptibility to chloramphenicol.Though the number of collected invasive S. pyogenes isolates decreased slightly in 2020 in comparison to previous years, iGAS disease remains an important public health concern. The emm distribution in Canada has been subtly shifting over the past five years, away from common and well-known emm1 and towards emm49 and emm76. It is important to continue surveillance of S. pyogenes in Canada to monitor expanding replacement emm types, as well as outbreak clones and antimicrobial resistance.
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