医学
四分位数
内科学
结直肠癌
胰岛素抵抗
前瞻性队列研究
危险系数
入射(几何)
甘油三酯
比例危险模型
胃肠病学
癌症
胰岛素
置信区间
胆固醇
物理
光学
作者
Tong Liu,Qingsong Zhang,Yiming Wang,Xiangming Ma,Qi Zhang,Mengmeng Song,Liying Cao,Hanping Shi
出处
期刊:BMC Cancer
[Springer Nature]
日期:2022-09-22
卷期号:22 (1)
被引量:22
标识
DOI:10.1186/s12885-022-10100-w
摘要
Abstract Background No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population. Methods In this prospective cohort study, we included 93,659 cancer-free participants with the measurements of TyG index and TG/HDL-C ratio. Participants were divided by the quartiles of the TyG index or TG/HDL-C ratio. The associations of TyG index, TG/HDL-C ratio, and their components with CRC risk were assessed using Cox proportional hazards regression models. Results During a median follow-up of 13.02 years, 593 incident CRC cases were identified. Compared with the lowest quartile of the TyG index (Q1), the risk of CRC was higher in persons in the third (Q3) and highest quartiles (Q4) of the TyG index, with corresponding multivariable-adjusted HRs (95% CI) of 1.36 (1.06, 1.76) and 1.50 (1.19, 1.91), respectively. The elevated risks of CRC incidence were observed in people in the second, third, and highest quartiles of the TG/HDL-C ratio groups, with corresponding multivariable-adjusted HRs (95% CI) of 1.33 (1.05, 1.70), 1.36 (1.07, 1.73) and 1.37 (1.07, 1.75), respectively. Conclusions Elevated TyG index and TG/HDL-C ratio were associated with a higher risk of developing CRC among adults in Northern China.
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