基因分型
遗传学
基因型
时钟
多态性(计算机科学)
生物钟
心理学
基因
生物
医学
作者
Alfonso Cabrera-Lagunes,Adriana Díaz-Anzaldúa,Gustavo Rojas Andrade,Vanessa-Giselle Peschard,Adriana Arias Caballero,César Enrique Gaspar-Barba,Arlette Yunes Jimenez,Francisco Rafael De la Peña Olvera,Carlos Sabás Cruz Fuentes,Miriam Feria-Aranda,Liz Sosa Mora,Armando Pérez Molina,Diana Guizar Sanchez,Lino Palacios‐Cruz
标识
DOI:10.1016/j.psychres.2022.114835
摘要
This study aimed to evaluate markers of the CLOCK gene rs1801260 and rs4864548 in Mexican adolescents, addressing clinical and biological aspects previously associated with ADHD. 347 Mexican adolescents were assessed for mental disorders, metabolic disruption and related conditions, circadian preference, as well as genotyping for the CLOCK. We found a significant association between ADHD and the AA and AG genotypes of rs1801260. Also, we identified in the ADHD group that the total Triiodothyronine and total Thyroxine values were respectively 10 ng/dl units and 0.58 ug/dl units lower in females than in males. Previously reported common variations of the CLOCK gene have been associated with ADHD like the Rs1801260 polymorphism hereby we could consider it as risk factor, but genetic, biochemical and clinical studies in the Mexican population are entailed.
科研通智能强力驱动
Strongly Powered by AbleSci AI