生物相容性
聚己内酯
紫杉醇
PLGA公司
涂层
镁合金
材料科学
新生内膜增生
血管内皮生长因子
再狭窄
生物医学工程
支架
镁
冶金
医学
外科
复合材料
纳米技术
聚合物
癌症研究
纳米颗粒
血管内皮生长因子受体
化疗
作者
Ume Farwa,Hyun-Yong Lee,H. Lim,Ihho Park,Sang‐Ho Park,Byoung-Gi Moon,Omar Faruq
标识
DOI:10.1016/j.ijbiomac.2023.126218
摘要
Despite significant advancements made in cardiovascular stents, restenosis, thrombosis, biocompatibility, and clinical complications remain a matter of concern. Herein, we report a biodegradable Mg alloy stent with a dual effect of the drug (Paclitaxel) and growth factor (VEGF) release. To mitigate the fast degradation of Mg alloy, inorganic and organic coatings were formed on the alloy surface. The optimized hierarchal sequence of the coating was the first layer consisting of magnesium fluoride, followed by poly(l-lactide) and hydroxyapatite coating, and finally sealed by a polycaprolactone layer (MgC). PLLA and HAp were used to increase the adhesion strength and biocompatibility of the coating. Paclitaxel and VEGF were loaded in the final PCL layer (Mg-C/PTX-VEGF). As compared to bare Mg alloy (28 % weight loss), our MgC system showed (3.1 % weight loss) successful decrease in the degradation rate. Further, the in vitro biocompatibility illustrated the highly biocompatible nature of our drug and growth factor-loaded system. The in vivo results displayed that the drug loading decreased the inflammation and neointimal hyperplasia as indicated by the α-SMA and CD-68 antibody staining. The growth factor helped in the endothelialization which was established by the FLKI and ICAM antibody staining of the tissue.
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