纳米技术
生物相容性
材料科学
粘附
稳健性(进化)
组织工程
纳米颗粒
自愈水凝胶
计算机科学
生物医学工程
化学
复合材料
工程类
生物化学
高分子化学
冶金
基因
作者
Zhao Pan,Qiqi Fu,Mohan Wang,Huai‐Ling Gao,Liang Dong,Pu Zhou,Dongdong Cheng,Ying Chen,Duohong Zou,Jiahui He,Xue Feng,Shu‐Hong Yu
标识
DOI:10.1038/s41467-023-40753-5
摘要
Nanoparticles-based glues have recently been shown with substantial potential for hydrogel adhesion. Nevertheless, the transformative advance in hydrogel-based application places great challenges on the rapidity, robustness, and universality of achieving hydrogel adhesion, which are rarely accommodated by existing nanoparticles-based glues. Herein, we design a type of nanohesives based on the modulation of hydrogel mechanics and the surface chemical activation of nanoparticles. The nanohesives can form robust hydrogel adhesion in seconds, to the surface of arbitrary engineering solids and biological tissues without any surface pre-treatments. A representative application of hydrogel machine demonstrates the tough and compliant adhesion between dynamic tissues and sensors via nanohesives, guaranteeing accurate and stable blood flow monitoring in vivo. Combined with their biocompatibility and inherent antimicrobial properties, the nanohesives provide a promising strategy in the field of hydrogel based engineering.
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