化学
Diels-Alder反应
桤木
冷凝
有机化学
表面改性
组合化学
催化作用
植物
热力学
物理
物理化学
生物
作者
Elizabeth C. Swift,Zachary S. Sales,Dongpei Wu,Anastassia Matviitsuk,Daniel J. Pippel,Terry P. Lebold
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-11-22
卷期号:25 (48): 8711-8715
被引量:1
标识
DOI:10.1021/acs.orglett.3c03481
摘要
A method for the preparation of highly functionalized 4-iodo-7-azaindazoles is reported. These valuable heterocycles are synthesized via condensation of 2-hydrazineylpyrimidines with various iodoalkynones followed by Diels-Alder/retro-Diels-Alder cyclization. The method is general to the formation of products with a variety of C3, C5, and C6 substituents while preserving the C4 iodide functional handle for further late-stage functionalization. The utility of this transformation is demonstrated through the rapid synthesis of several bioactive azaindazole targets.
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