光热治疗
光动力疗法
谷胱甘肽
癌症研究
肿瘤缺氧
肿瘤微环境
化学
纳米技术
医学
材料科学
生物化学
放射治疗
肿瘤细胞
内科学
酶
有机化学
作者
Zheng Yang,Ronghua Shi,Liu Xuan,Qiuna Zhang,Mengyao Chen,Yuhua Shen,Yuhua Shen,Manzhou Zhu
出处
期刊:ACS materials letters
[American Chemical Society]
日期:2023-08-02
卷期号:5 (9): 2361-2368
被引量:5
标识
DOI:10.1021/acsmaterialslett.2c01043
摘要
The complexities of light penetration, short 1O2 life, severe tumor hypoxia, overexpressed reductive glutathione (GSH), and acidic conditions in the tumor microenvironment (TME) limit the success of photobased multimodal combined therapy (MCT) in anticancer. Herein, the mitochondria targeting nanoadapters with multistimulus responsibility are fabricated for the photothermal imaging guided MCT. The obtained Au NCs@MBA-TPP NAPs can be triggered simultaneously by overexpressed H2O2 and GSH in TME, as well as near-infrared (NIR) laser, achieving chemodynamic therapy (CDT), NIR motivated photothermal therapy (PTT) and photodynamic therapy (PDT). Furthermore, the hematosin in Au NCs@MBA-TPP NAPs causes O2-generation and GSH depletion for the enhancement of PDT and CDT with the mitochondria targeting enhanced MCT effectively by the photothermal imaging guide. Hence, our design provides a new strategy for the integration of diagnosis and treatment with TME modulation to potentially improve the MCT in tumor treatment potentially.
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